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Louis s goodman biography of williams

          The Louis S. Goodman papers () contain correspondence, memorandums, notes, articles, research, conference materials, galley proofs, lecture notes.

        1. The Louis S. Goodman papers () contain correspondence, memorandums, notes, articles, research, conference materials, galley proofs, lecture notes.
        2. Mr.
        3. He was a phamacologist who helped develop the chemical treatment of cancer.
        4. By Louis S. Goodman, Maxwell M. Wintrobe, William Dameshek, Morton J. Goodman, Alfred Gilman and Margaret T. McLennan.
        5. Louis W. Goodman is Dean and Professor of International Relations at American University's School of.

          6. He was a phamacologist who helped develop the chemical treatment of cancer..

          Mouse Lymphoma

          The remarkable sensitivity and vulnerability of rapidly proliferating cells and lymphoid tissues suggested that the mustards might effectively treat lymphoid tumors.

          Goodman and Gilman showed their rabbit data to Thomas Dougherty, a Yale anatomy professor, and he agreed to assist with the first efficacy studies.16,19

          Sulfur mustard had undesirable physical properties for these studies.16 It was volatile, quite insoluble, unstable in water, dangerous to handle and difficult to administer.17

          The nitrogen mustard analogs were slightly less reactive than sulfur mustard.16,21 They formed non-volatile, water-soluble hydrochloride salts, could be handled safely, and could be administered intravenously.16,17

          In the first series of experiments, they injected mice to determine the acute lethal dose and the dose that could be given daily without drastically affecting bone marrow.19

          By chance, Dougherty had implanted a mouse with lymphoma, and the tumor was fai